In vivo Antimalarial Activity of a Labdane Diterpenoid from the Leaves of Otostegia integrifolia Benth
Identifieur interne : 001207 ( Main/Exploration ); précédent : 001206; suivant : 001208In vivo Antimalarial Activity of a Labdane Diterpenoid from the Leaves of Otostegia integrifolia Benth
Auteurs : Abyot Endale [Éthiopie] ; Daniel Bisrat [Éthiopie] ; Abebe Animut [Éthiopie] ; Franz Bucar [Autriche] ; Kaleab Asres [Éthiopie]Source :
- Phytotherapy Research [ 0951-418X ] ; 2013-12.
English descriptors
- Teeft :
- Ababa, Addis, Addis ababa, Addis ababa university, Aklilu lemma institute, Antimalarial, Antimalarial activity, Antiplasmodial, Antiplasmodial activity, Aqueous fraction, Berghei, Body weight, Cell volume, Chloroquine, Diterpenoids, Dos, Ethiopia, Ethnopharmacol, Etoac, Etoac fraction, Hair erection, Humana press, Hydroalcoholic leaf, Integrifolia, Integrifolia leaf, John wiley sons, Labdane diterpenoid, Malaria, Medicinal plants, Melaku wondafrash, Methanol leaf, National herbarium, Negative control, Other hand, Otostegia, Otostegia integrifolia, Otostegia integrifolia benth, Otostegindiol, Parasitaemia, Parasitaemia level, Parasite growth, Parasitized erythrocytes, Percent suppression, Percentage suppression, Pharmaceutical chemistry, Plant material, Plasma membrane, Plasmodium, Plasmodium berghei, Present study, Products isolation, Pycnanthus angolensis, Single dose, Slight reduction, Solvent fractions, Swiss albino mice, Toxicity, Toxicity test, Vivo antimalarial activity.
Abstract
In Ethiopian traditional medicine, the leaves of Otostegia integrifolia Benth. are used for the treatment of several diseases including malaria. In an ongoing search for effective, safe and cheap antimalarial agents from plants, the 80% methanol leaf extract O. integrifolia was tested for its in vivo antimalarial activity, in a 4‐day suppressive assay against Plasmodium berghei. Activity‐guided fractionation of this extract which showed potent antiplasmodial activity resulted in the isolation of a labdane diterpenoid identified as otostegindiol. Otostegindiol displayed a significant (P < 0.001) antimalarial activity at doses of 25, 50 and 100 mg/kg with chemosuppression values of 50.13, 65.58 and 73.16%, respectively. Acute toxicity studies revealed that the crude extract possesses no toxicity in mice up to a maximum dose of 5000 mg/kg suggesting the relative safety of the plant when administered orally. The results of the present study indicate that otostegindiol is among the antimalarial principles in this medicinal plant, and further support claims for the traditional medicinal use of the plant for the treatment of malaria. Copyright © 2013 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.4948
Affiliations:
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In an ongoing search for effective, safe and cheap antimalarial agents from plants, the 80% methanol leaf extract O. integrifolia was tested for its in vivo antimalarial activity, in a 4‐day suppressive assay against Plasmodium berghei. Activity‐guided fractionation of this extract which showed potent antiplasmodial activity resulted in the isolation of a labdane diterpenoid identified as otostegindiol. Otostegindiol displayed a significant (P < 0.001) antimalarial activity at doses of 25, 50 and 100 mg/kg with chemosuppression values of 50.13, 65.58 and 73.16%, respectively. Acute toxicity studies revealed that the crude extract possesses no toxicity in mice up to a maximum dose of 5000 mg/kg suggesting the relative safety of the plant when administered orally. The results of the present study indicate that otostegindiol is among the antimalarial principles in this medicinal plant, and further support claims for the traditional medicinal use of the plant for the treatment of malaria. 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